Saturday, November 27, 2010
Thursday, November 25, 2010
The Sign
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Wednesday, November 24, 2010
Bypass surgery might be history soon...
In a groundbreaking discovery that may eventually render bypass surgery history, researchers at Tel Aviv University have shown that an injected protein can regrow blood vessels in the human heart.
In heart disease, blood vessels are either clogged or die off, starving the heart of oxygen and leaving it highly susceptible to a cardiac attack.
Dr. Britta Hardy of TAU's Sackler School of Medicine and her team of researchers have developed a protein-based injection that when delivered straight to muscles in the body, sparks the regrowth of tiny blood vessels.
The new vessels in the heart could give millions of people around the world a new lease of life.
"The biotechnology behind our human-based protein therapy is very complicated, but the goal is simple and the solution is straightforward. We intend to inject our drug locally to heal any oxygen-starved tissue. So far in animal models, we've seen no side effects and no inflammation following our injection of the drug into the legs. The growth of new blood vessels happens within a few weeks, showing improved blood circulation," said Hardy.
The protein solution can also be added as a coating to a stent. Usually, the implantation of a stent is accompanied by a high risk for blood clots, which necessitates the use of blood thinners.
"We could coat a stent with our peptide, attracting endothelial stem cells to form a film on the surface of the stent. These endothelial cells on the stent would eliminate the need for taking the blood thinners that prevent blood clots from forming," said Hardy.
If investment goals are met, the researchers are hoping that toxicity studies and Phase I trials could be complete within two years.
The researchers began the study for preventing leg amputations, positing that proteins from the human body could be used to trigger the growth of new blood vessels.
Hardy started by studying a library of peptides and testing them in the laboratory and later confirmed initial results.
She then took some of the isolated and synthesized peptides and tested them in diabetic mice whose legs were in the process of dying.
Although diabetes is known to decrease blood circulation, Hardy found that her therapy reversed the decrease.
"Within a short time we saw the formation of capillaries and tiny blood vessels. After three weeks, they had grown and merged together with the rest of the circulatory system," she said.
In mice with limited blood circulation, she was able to completely restore blood vessels and save their legs.
It was then a short step to studying the applicability of the research to cardiac patients.
"It''s pretty obvious if there is regrowth or not... our technology promises to regrow blood vessels like a net, and a heart that grows more blood vessels becomes stronger. It's now imaginable that, in the distant future, peptide injections may be able to replace bypass surgeries," concluded Hardy.
The study has been published in Biochemical Pharmacology.
Enjoy the rest of your week..
Love,
Prof. Dr. Alex Abraham Odikandathil
Wednesday, November 17, 2010
Creation's debate
Entering the ongoing debate between faith and science, renowned British scientist Stephen Hawking claims that modern physics has now proved that God played no role in the creation of the universe.
In a new book -- "The Grand Design" co-written with American physicist Leonard Mlodinow -- the theoretical physicist sets out to demolish Sir Issac Newton's claim that an "intelligent and powerful Being" must have shaped the universe, which he believed could not have emerged from chaos. Hawking and Mlodinow rule out the possibility of divine intervention, saying that new theories have made the idea of a supernatural creator redundant.
"Because there is a law such as gravity, the universe can and will create itself from nothing," the pair write, in an extract published in London Times a fortnight ago. "Spontaneous creation is the reason there is something rather than nothing, why the universe exists, why we exist. It is not necessary to invoke God to light the blue touch paper and set the Universe going."
"The Grand Design," which goes on sale next week, is a significant shift away from Hawking's previous comments on the divine. In his 1988 best-seller, "A Brief History of Time", he suggested that it was possible to believe in the concept of God as creator and also held a scientific view of the universe. "If we do discover a complete theory ... of why it is that we and the universe exist ... it would be the ultimate triumph of human reason -- for then we would know the mind of God," he wrote.
And in a 2007 interview, he appeared to portray himself as an agnostic. "I believe the universe is governed by the laws of science," he told the BBC. "The laws may have been decreed by God, but God does not intervene to break the laws."
Hawking now argues that Newton's assertion that the laws of nature cannot alone explain the existence of life and the universe started to fall apart in 1992, when astronomers discovered the first extra-solar planets (planets beyond our own solar system) orbiting other sunlike stars.
"That makes the coincidences of our planetary conditions -- the single Sun, the lucky combination of Earth-Sun distance and solar mass, far less remarkable, and far less a compelling evidence that the Earth was carefully designed just to please us human beings," he writes. Hawking believes that other universes, as well as other solar systems, are also likely to exist. But if God's purpose was to create mankind, he wonders, why would He make these out-of-reach worlds?
Richard Dawkins, an evolutionary biologist and a high-profile atheist, welcomed the book, telling the Times that Hawking had developed a theory of Darwinism for the entirety of nature, not simply the creatures that live within it. "That's exactly what he's saying," Dawkins told the paper. "I know nothing of the details of physics, but I had always assumed the same thing."
"If all the physical laws had been explained and proved -- which is a million miles from the case -- our understanding of the actions of God would not be one whit greater: his existence and his actions are of a different order," writes Quentin de la Bedoyere, science editor of the U.K.'s Catholic Herald newspaper. "Most particularly it would not touch the question of how something existing comes out from nothing. That is a question which science cannot answer, and will never answer, because nothingness is not within its domain. ... Neither [Hawking], nor you, nor I will ever explain creation, except through faith."
Sunday, November 14, 2010
Prayer of Faith
Here I'm only reproducing a beautiful story written by a doctor who was working in South Africa.
"One night I had worked hard to help a mother in the labor ward; but in spite of all my efforts, she died leaving us
We also had no special feeding facilities. Although we lived on the equator, nights were often chilly with treacherous drafts. One student-midwife went for a box and cotton wool that the baby could be wrapped in.
Another went to stoke up the fire and fill a hot water bottle. She came back shortly in distress to tell me that in filling the bottle, it had burst (rubber explodes easily in tropical climate). And it was our last hot water bottle! As in the West, it is no good crying over spilt milk, so in Central Africa it might be considered no good crying over burst water bottles. They do not grow on trees, and there are no drugstores down forest pathways.
"Alright," I said, "put the baby as near to the fire as you safely can, and sleep between the baby and the door to keep it free from drafts. Your job is to keep the baby warm."
The following noon, as I did on most days, I went to pray with the orphanage-children who chose to gather with me...I gave the youngsters various suggestions to pray about and told them about the tiny baby. I explained our problem about keeping the baby warm enough, mentioning the hot water bottle and that the probability of the baby dying if it got chills. I also told them of the two-year-old sister,crying because her mother had died.
During prayer time, a ten-year old girl, Ruth, prayed with the usual blunt conciseness of our African children. "Please,God" she prayed, "send us a water bottle. It'll be no good tomorrow, God, as the baby will be dead, so
While I gasped at the audacity of the prayer, she added, "And while You are about it, would You please send a dolly for the little girl so she'll know You really love her?"
As often with children's prayers, I was puzzled. Could I honestly say, "Amen"? I just did not believe that God could do this. Oh! yes, I know that He can do everything, so the Holy Bible say... But there are limits, aren't there? The only way God could answer to this particular prayer would be by sending me a parcel from homeland. I had been in Africa for almost four years but had never received a parcel from home.
However, if anyone did send me a parcel, who would put a hot water bottle therein? I lived on the equator!
By the time I reached home, the car had gone, but there, on the veranda, was a large twenty-two pound parcel. I felt tears pricking my eyes. I could not open the parcel alone, so I sent for the orphanage children.
Together we pulled off the string, carefully undoing each knot. Excitement was mounting. Some thirty or forty pairs of eyes were focused on the large cardboard box. From the top, I lifted out brightly colored, knitted jerseys. Eyes sparkled as I gave them out. Then there were the knitted bandages for the leprosy patients, and the children looked a little bored. Then came a box of mixed raisins and sultanas - that would make a batch of buns for the weekend. Then, as I put my hand in again, I felt the ... could it really be? I grasped and pulled it out - yes, a brand-new, rubber hot water bottle.
She rushed forward, crying out, "If God has sent the bottle, He must have sent the dolly too!"
Rummaging down to the bottom of the box, she pulled out the small, beautifully dressed dolly.
Her eyes shone! She had never doubted, not even for a sec!
Looking up at me, she asked,
That parcel had been in transit for five whole months. Packed up by my former Sunday School Students, whose leader had heard and obeyed God's prompting to send a hot water bottle upto the equator. And one of the girls had put in a dolly for an African child - five months before, in answer to the believing prayer of a ten-year-old to bring it 'that afternoon'."
"Before they call, I will answer" (Isaiah 65:24).
No strings attached.
Prayer is one of the best gifts we receive. There is no cost but a lot of reward.
Let's continue praying for one another, with unparalleled faith in bringing blessings upon each other.
Wednesday, November 10, 2010
Managing our social circle; limitations.
Despite some people having 5,000 friends on their Facebook profiles, they may not be able to remember or manage more than 150 pals in real life, an expert claims. Robin Dunbar, professor of Evolutionary Anthropology at Oxford University, falls back on a theory he developed in the 1990s, known as 'Dunbar's number,' to prove his point.
The theory claims that the size of our neocortex - the part of the brain used for conscious thought and language - limits us to managing a social circle of around 150 friends, no matter how sociable we are. The figure was reached after Dunbar checked how many people contacted at least once a year in a variety of societies, ranging from neolithic villages to modern office environments. Now he has applied his theory to studying social networking websites. And, he insists that the "Facebook effect" has hardly had an impact on the size of social groupings.
"The interesting thing is that you can have 1,500 friends but when you actually look at traffic on sites, you see people maintaining the same inner circle of around 150 people that we observe in the real world," Timesonline quoted Dunbar as saying. He added: "People obviously like the kudos of having hundreds of friends but the reality is that they're unlikely to be bigger than anyone else's.
"There is a big sex difference though ... girls are much better at maintaining relationships just by talking to each other. Boys need to do physical stuff together." Dunbar's study is expected to be published later this year.
Think about it while enjoying the rest of your weekend,
love,
Prof. Dr. Alex Abraham Odikandathil